Anti-OPRM1 (phospho S375) Antibody

This rabbit polyclonal antibody from Antibodies.com targets OPRM1 (mu-opioid receptor) when phosphorylated at serine 375, a regulatory residue central to mu-opioid receptor desensitization, internalization, and downstream signaling cascades. Raised in rabbits and supplied as an unconjugated IgG polyclonal reagent in a 200 µl vial, the antibody is validated for Western Blot detection across human, mouse, and rat samples. Phosphorylation at S375, largely mediated by GRK kinases following agonist binding, marks a key biochemical step in opioid tolerance and receptor downregulation, making the reagent useful for research into pain modulation, addiction biology, and GPCR signaling. The cross-species reactivity supports comparative studies in rodent models and human cell lines, and aliquoting on receipt is recommended to preserve phospho-specific binding activity across repeated uses.