Anti-OPRM1 (phospho S375) Antibody

Phosphorylation at serine 375 of the mu-opioid receptor (OPRM1) is a key regulatory event linked to agonist-induced desensitization, internalization, and downstream signaling after opioid ligand binding. This rabbit polyclonal antibody from Antibodies.com is raised against the phospho-S375 epitope and is validated for Western blot detection across human, mouse, and rat samples, supporting neuroscience and opioid receptor pharmacology studies that compare ligand-stimulated versus basal phosphorylation states in cell or tissue lysates.

Supplied as an unconjugated IgG in a 100 µl volume, the reagent fits standard immunoblotting workflows and resolves the receptor as a monomer and as higher-molecular-weight glycosylated species. The polyclonal format provides multiple epitope contacts around S375, which can improve signal recovery when the target is expressed at low abundance. Typical working dilutions sit in the ranges commonly used for phospho-specific primary antibodies on nitrocellulose or PVDF membranes, paired with HRP- or fluorophore-conjugated secondary reagents for chemiluminescent or fluorescent read-out, and the S375 marker's involvement in receptor endocytosis makes it a useful readout in desensitization time-course experiments.

Handle the antibody as a temperature-sensitive reagent: store at -20°C, preferably in single-use aliquots to limit repeated freeze-thaw cycles, and centrifuge briefly before opening to recover the full volume. For research use only.