Anti-OPG Antibody

Raised in rabbit against the osteoprotegerin (OPG) target, this unconjugated polyclonal reagent from Antibodies.com is supplied as a 100 µl volume for western blot, immunohistochemistry, immunofluorescence, and ELISA workflows. OPG, also called TNFRSF11B, is a soluble decoy receptor released by osteoblasts that binds RANKL and thereby controls osteoclast formation, so it is central to studies of bone density, osteoporosis, vascular calcification, periodontitis, rheumatoid bone erosion, and bone-metastatic disease. The antibody reacts with human and mouse OPG, allowing parallel work across species in translational projects. As a polyclonal reagent it recognizes multiple epitopes on the protein, supporting detection of both denatured antigen in lysates and native protein in fixed tissue sections. The product ships as one vial; on arrival it should be aliquoted to limit freeze-thaw cycles and held frozen for long-term stability, with brief refrigerated use between runs. Laboratories profiling the RANK/RANKL/OPG axis, screening serum biomarker candidates for bone turnover, or mapping OPG expression in tumor microenvironments will find this reagent a practical primary detection tool.