Anti-OPA1 Antibody

Detect endogenous OPA1, a dynamin-related mitochondrial GTPase that regulates inner membrane fusion, cristae remodeling, and apoptotic cytochrome c release, with this rabbit polyclonal antibody from Antibodies.com. Raised against OPA1 and validated for western blot, the reagent recognizes the expected long and short isoforms generated by proteolytic cleavage of the precursor in lysates from human, mouse, and rat cells.

Supplied at 1 mg/ml in phosphate buffered saline (PBS) containing 15 mM sodium azide at approximately pH 7.2, packaged in a 100 µl vial. OPA1 sits at the intersection of mitochondrial dynamics, mtDNA maintenance, and metabolic stress signaling, so this reagent supports studies of fusion/fission balance, neurodegeneration (including dominant optic atrophy, in which heterozygous OPA1 mutations cause progressive retinal ganglion cell loss), and apoptosis pathways. Use it on standard SDS-PAGE/WB workflows with mitochondrial fractions or whole-cell extracts; follow with an HRP- or fluorophore-conjugated secondary appropriate for the host species.

Store refrigerated; protect from prolonged light exposure and avoid repeated freeze-thaw cycles to preserve reagent integrity. For research use only.