Anti-Op18 Antibody

Raised in rabbit against the oncoprotein 18 (Op18) target, this polyclonal reagent from Antibodies.com supports cell-cycle and oncology research workflows. Op18, also known as Stathmin 1 (STMN1), is a 19 kDa microtubule-destabilizing phosphoprotein that regulates mitotic spindle dynamics through phosphorylation by CDK1, MAPK, and CaMKIV at serine residues 16, 25, 38, and 63.

The unconjugated antibody is supplied as 100 µl of ready-to-use stock and is validated for Western blot, immunohistochemistry, immunofluorescence, and ELISA applications. Reactivity studies confirm detection of the endogenous human, mouse, and rat proteins, enabling comparative work across model systems and patient-derived tissue samples.

Researchers studying hematological malignancies, hepatocellular carcinoma, breast cancer, or neuronal development rely on Op18 immunolabeling to monitor proliferative indices and mitotic arrest. Storage at -20 °C in single-use aliquots preserves antibody activity through repeated freeze-thaw cycles, and a brief centrifugation step before each use removes any protein aggregates that may accumulate over time.

This Antibodies.com primary antibody pairs cleanly with anti-phospho-Stathmin reagents for kinase signaling studies and complements Ki-67 or PCNA immunostaining in tumor proliferation panels, supporting both routine chromogenic detection and quantitative image analysis pipelines.