Anti-Op18 Antibody

Oncoprotein 18 (Op18), also known as Stathmin 1, is a ~19 kDa cytoplasmic phosphoprotein that destabilizes microtubules by sequestering free tubulin heterodimers and is widely studied as a marker of mitotic activity and tumor aggressiveness. This rabbit polyclonal antibody from Antibodies.com is raised against Op18, supplied at 1 mg/ml in phosphate-buffered saline (approximately pH 7.2) with 0.05% sodium azide, and validated for western blot, immunohistochemistry, immunocytochemistry, and immunoprecipitation workflows. The unconjugated reagent shows reactivity with human, mouse, and rat samples, enabling comparative studies of Op18 expression across normal and neoplastic tissues, including leukemia, neuroblastoma, glioma, and breast carcinoma models where elevated Op18 correlates with proliferative index and prognosis. Researchers commonly use this reagent to track cell-cycle-dependent phosphorylation at Ser16, Ser25, Ser38, and Ser63, the principal regulatory sites targeted by CDK1, MAP kinases, and PKA. Storage should follow standard practice: refrigerate the working aliquot at 4°C and protect from light; avoid repeated freeze-thaw cycles of the stock. The 100 µL vial size provides sufficient material for dozens of mini-gel immunoblots and multiple IHC slides depending on dilution.