Anti-OGT Antibody

This rabbit polyclonal primary antibody from Antibodies.com targets OGT (O-linked N-acetylglucosamine (GlcNAc) transferase), the enzyme responsible for adding a single O-GlcNAc moiety to serine and threonine residues of nuclear and cytoplasmic proteins. OGT is essential for nutrient sensing, transcription regulation, and stress response pathways, and is widely studied in the context of post-translational modification research, metabolic disease, and neurobiology.

Supplied in a 100 µl vial of 1 mg/ml stock in PBS with 0.1% sodium azide and 50% glycerol, the unconjugated antibody is affinity purified and validated for western blot, immunohistochemistry, immunofluorescence, and immunoprecipitation. It cross-reacts with human, mouse, and rat samples, supporting comparative studies across common model systems. Researchers use this reagent to investigate O-GlcNAcylation dynamics, map OGT substrates, and probe the enzyme's role in cell signaling, epigenetic regulation, and disease mechanisms. Aliquoting upon arrival and storage at -20°C protects activity across multiple freeze-thaw cycles for long-term experimental workflows.