Anti-OGT Antibody

O-linked N-acetylglucosamine transferase (OGT) is a key regulatory enzyme that catalyzes the addition of O-GlcNAc to serine and threonine residues on nuclear and cytoplasmic proteins. This rabbit polyclonal primary antibody from Antibodies.com is raised against OGT and supplied as an unconjugated IgG preparation in a 100 µl volume.

The reagent is validated for Western blot (WB) and immunohistochemistry (IHC) workflows, supporting detection of endogenous OGT across immunoblotting and fixed-tissue staining applications. Cross-reactivity is confirmed for human, mouse, and rat samples, allowing comparative studies in cell lines, primary cultures, and tissue sections derived from these species.

Researchers use anti-OGT antibodies to investigate O-GlcNAc cycling, nutrient and stress sensing, insulin signaling, and the role of post-translational glycosylation in metabolic disease, neurodegeneration, and oncology. The unconjugated format enables flexible labeling with secondary reporters of the researcher's choice, including HRP, fluorophore, or biotin conjugates, depending on the experimental platform.