Anti-OGG1 Antibody

OGG1 (8-oxoguanine DNA glycosylase) is a base excision repair enzyme that excises 8-oxoguanine lesions from DNA, counteracting damage from reactive oxygen species. This polyclonal reagent from Antibodies.com was raised in rabbit hosts and is supplied as an unconjugated preparation at approximately 1 mg/ml in phosphate buffered saline containing 0.05% sodium azide, pH roughly 7.2.

The antibody is validated for western blot and immunohistochemistry applications and shows reactivity with Human, Mouse, and Rat samples, making it suitable for cross-species studies of oxidative DNA damage, genomic instability, age-related disease models, and carcinogenesis pathways. It is supplied in a 100 µl vial format that supports multiple rounds of immunoblotting or tissue staining experiments. Because the target is a glycosylase rather than a structural antigen, results can vary with fixation conditions and sample handling, so users often pair it with appropriate controls.

OGG1 expression patterns are commonly examined in neurodegeneration research, where 8-oxoG accumulation has been implicated in disease progression, and in tumor biology studies, where OGG1 status correlates with mutational burden and treatment response. Aliquots may be refrigerated for routine short-term use, with working stocks stored frozen to preserve antibody activity across repeated freeze-thaw cycles.