Anti-Ob-R Antibody

This Rabbit polyclonal antibody targets the leptin receptor (Ob-R/LepRb), a class I cytokine receptor that mediates leptin signaling in hypothalamic circuits controlling energy homeostasis, appetite, and body weight regulation. Distributed by Antibodies.com as an unconjugated IgG preparation, the reagent is validated for Western blot and ELISA workflows and shows reactivity with Human samples. The 100 µl vial size supports multiple immunoblot and plate-based assays, and the polyclonal antibody recognizes multiple epitopes across the long intracellular, extracellular, and cytoplasmic isoforms produced by alternative splicing of LEPR transcripts.

Ob-R is widely expressed in the hypothalamus, liver, adipose tissue, pancreatic islets, and immune cells, making this antibody useful for studies of obesity, type 2 diabetes, metabolic syndrome, inflammation, and reproductive biology. Researchers commonly apply it to characterize leptin receptor isoform expression, investigate JAK2/STAT3 signaling downstream of ligand binding, or compare receptor abundance in lean versus obese patient-derived samples. The unconjugated format provides flexibility in fluorophore or enzyme selection, allowing researchers to pair the antibody with secondary reagents matched to their experimental design.