Anti-Ob-R Antibody

For laboratories investigating leptin signaling and metabolic regulation, this rabbit polyclonal antibody from Antibodies.com recognizes the human leptin receptor (Ob-R/LEPR), a single-transmembrane cytokine receptor that mediates the satiety and energy-expenditure effects of adipocyte-derived leptin through JAK/STAT, PI3K/Akt, and MAPK cascades.

Validated for Western blot and immunohistochemistry, the reagent supports detection of receptor expression in cell lysates and tissue sections, including hypothalamic regions where leptin-responsive neurons of the arcuate nucleus are concentrated. Researchers studying monogenic obesity linked to LEPR mutations, type 2 diabetes, adipokine biology, or food-intake circuits can use this antibody to examine receptor abundance, isoform distribution, and downstream activation state.

Supplied at 100 µl per vial, the antibody is formulated at 1 mg/ml in PBS with 0.1% sodium azide as preservative and 50% glycerol for storage stability. The unconjugated format permits pairing with user-selected secondary reagents for chromogenic, fluorescent, or chemiluminescent readout. Reactivity is confirmed against human samples, and the polyclonal backbone targets multiple epitopes across the long and short receptor isoforms, providing flexibility for both qualitative localization work and semi-quantitative expression analysis in research-use-only studies.