Anti-OAT1 Antibody

Produced in rabbit and raised against the Organic Anion Transporter 1 (SLC22A6) membrane protein, this unconjugated primary antibody from Antibodies.com is supplied as a 100 µl aliquot validated for Western blot and ELISA workflows with reactivity to human samples. OAT1 is predominantly localized to the basolateral membrane of renal proximal tubule epithelial cells, where it mediates the uptake of endogenous organic anions, drug metabolites, and environmental toxins from the bloodstream into the kidney for urinary excretion. Researchers studying drug-drug interactions, renal pharmacology, nephrotoxicity, and xenobiotic clearance pathways commonly use anti-OAT1 antibodies to characterize transporter expression in cell lines, kidney biopsy material, and overexpression systems. The polyclonal format provides recognition of multiple epitopes on the SLC22A6 transporter, which is advantageous when probing expression levels or localization changes under varying physiological, pharmacological, or disease-state conditions. For storage, the antibody should be kept refrigerated and protected from repeated freeze-thaw cycles to preserve activity across multiple experiments.