Anti-OASL Antibody

This polyclonal rabbit IgG antibody targets human OASL (2'-5'-oligoadenylate synthetase-like), an interferon-stimulated gene product that contributes to innate antiviral defense. Raised in rabbit and supplied as an unconjugated IgG preparation at 50 µl per vial, this reagent from Antibodies.com is validated for Western blot and immunohistochemistry workflows on human samples. OASL is best known for its role in type I interferon signaling: although it lacks robust catalytic 2'-5'-oligoadenylate synthetase activity, it potentiates RIG-I-mediated pattern recognition and supports downstream antiviral gene expression, which makes antibodies against it useful for studies of viral restriction, innate immune regulation, and interferon pathway activation in both cell-based and tissue-based assays. As an unconjugated primary antibody, it can be paired with a wide selection of HRP- or fluorophore-conjugated secondaries, giving researchers flexibility in detection chemistry and signal amplification strategy.