Anti-OASL Antibody

The OASL (2'-5'-oligoadenylate synthetase-like) antiserum from Antibodies.com is an unconjugated, rabbit-derived polyclonal IgG reagent supplied as 200 \u00b5l in a single vial and validated for western blot and immunohistochemistry on human samples. OASL is an interferon-stimulated gene product that lacks catalytic 2'-5' oligoadenylate synthetase activity but instead supports innate antiviral signaling by enhancing RIG-I pathway activity, which is why it is a frequently studied marker in interferon biology and host-pathogen research.

This polyclonal antibody is used to detect endogenous human OASL protein in lysates of cultured cells and in fixed tissue sections. Investigators apply it to characterize type I interferon signaling cascades, viral restriction mechanisms relevant to RNA virus infection, and altered OASL expression in autoimmune and inflammatory disease models. Because the reagent is supplied unconjugated, it pairs readily with a user-selected secondary reporter \u2014 HRP, biotin, fluorophore, or alkaline phosphatase \u2014 chosen to match the chosen detection platform.

For handling, store the vial refrigerated at 4\u00b0C for short-term use; for longer storage, aliquot the antiserum and freeze it to limit freeze-thaw cycles. Working dilutions should be titrated empirically per application, with common starting ranges of 1:500 to 1:2000 for western blot and 1:100 to 1:500 for immunohistochemistry. Centrifuge the vial briefly before each use to recover the full liquid volume from the cap and walls.