Anti-OAS1 Antibody

The OAS1 protein (2'-5'-oligoadenylate synthetase 1) is an interferon-induced enzyme central to innate antiviral defense, where it polymerizes ATP into 2'-5'-linked oligoadenylates that activate latent RNase L and trigger degradation of viral RNA in infected cells. This rabbit polyclonal reagent from Antibodies.com is raised against OAS1 and shipped as an unconjugated preparation in a 100 µl volume, ready for direct fluorescent labeling or pairing with a secondary antibody in standard detection workflows.

Validation has been performed on Western blot and immunofluorescence (IF) applications, and the antibody cross-reacts with OAS1 from human, mouse, and rat samples, supporting comparative studies across common model organisms. Researchers commonly use this reagent to monitor interferon-stimulated gene induction in cytokine-treated or virus-infected cultures, to track apoptotic signaling downstream of RNase L activation, and to localize OAS1 expression in fixed tissue sections. The polyclonal host response increases the probability of recognizing multiple epitopes on the target, which can be helpful when working with denatured lysates or when probing sequence conservation between species.

For handling, refrigerate the vial upon arrival, protect from light if an aliquot is reserved for long-term use, and limit freeze-thaw cycles to preserve binding activity. As with all primary antibodies, this product is intended for research use only and is not validated for diagnostic procedures.