Anti-NUP107 Antibody

This rabbit polyclonal antibody targets NUP107, a core scaffolding component of the nuclear pore complex's Nup107-160 subcomplex. NUP107 is essential for de novo NPC assembly, nucleocytoplasmic transport, and proper mitotic progression, where it contributes to stable kinetochore-microtubule attachment during cell division.

The unconjugated IgG reagent from Antibodies.com is validated for Western blot and immunohistochemistry applications and demonstrates reactivity against mouse samples. Each vial contains 100 µl of polyclonal antiserum, providing ample volume for multiple blotting and staining experiments. Researchers studying nuclear envelope architecture, NPC biogenesis, mitotic regulation, and renal disease can use this reagent to detect endogenous NUP107 in cell lysates and fixed tissue sections.

NUP107 variants have been linked to steroid-resistant nephrotic syndrome, making this antibody relevant for kidney disease models and mechanistic studies of glomerular pathology. The rabbit host and polyclonal clonality offer broad epitope coverage, supporting consistent detection across varied sample preparations in research use only workflows.