Anti-NTRK3 Antibody

Raised in rabbits as an unconjugated polyclonal IgG, this primary antibody targets the cytoplasmic tyrosine kinase domain of NTRK3, the 150 kDa high-affinity signalling receptor for neurotrophin-3 (NT-3). Affinity-purified and supplied from Antibodies.com as a 100 µl liquid vial, the reagent is validated for western blot detection of endogenous NTRK3 in lysates prepared from human and mouse cells and tissues, producing a band near the expected 150 kDa molecular weight.

Because activating gene fusions and point mutations in NTRK3 act as oncogenic drivers, the antibody is regularly used to characterise TrkC expression in secretory breast carcinoma, congenital infantile fibrosarcoma, papillary thyroid carcinoma, and subsets of high-grade glioma, as well as in studies benchmarking TRK inhibitors such as larotrectinib and entrectinib. The polyclonal format broadens coverage across multiple epitopes within the kinase region, and the unconjugated IgG preparation accepts standard HRP- or fluorophore-coupled secondary detection in routine immunoblotting workflows.

For bench use, the antibody is shipped in a glycerol-containing buffer and should be stored at -20 °C in working aliquots; brief handling on ice is appropriate, and repeated freeze-thaw cycles should be avoided to preserve binding activity. Researchers interrogating proprioceptive sensory neuron development, synaptic plasticity, neurotrophin signalling, and TRK-pathway oncology can deploy this reagent to compare receptor levels across matched neural and tumour samples.