Anti-NTRK2 (phospho Y705) Antibody

This phospho-specific polyclonal antibody from Antibodies.com selectively recognizes the activated form of NTRK2 (also known as TrkB) phosphorylated on tyrosine 705, a key autophosphorylation site within the receptor's kinase domain that marks ligand-driven TrkB signaling initiated by neurotrophins such as BDNF and NT-4. Raised in rabbit and affinity-purified as an IgG preparation, the reagent is supplied unconjugated in a 200 µl vial and is intended for western blot detection of phospho-TrkB across human, mouse, and rat samples, enabling researchers to monitor receptor activation in neuronal cell lines, primary neuron cultures, brain tissue lysates, and peripheral tissues where TrkB is expressed. Because Y705 phosphorylation is tightly coupled to receptor dimerization and downstream MAPK and PI3K signaling cascades, this antibody is widely used in studies of synaptic plasticity, learning and memory, neurodegeneration, and neurotrophin-driven tumor biology, and it pairs naturally with total NTRK2 antibodies for normalization of receptor expression versus activation state.