Anti-NTRK2 (phospho Y705) Antibody

This rabbit polyclonal IgG antibody from Antibodies.com selectively detects NTRK2 (also known as TrkB) when phosphorylated at tyrosine 705, an activation-loop residue within the receptor's intracellular tyrosine kinase domain. Phosphorylation at Y705 reflects ligand-driven activation of TrkB by BDNF and NT-4/5, making this reagent useful for probing neurotrophin signaling, neuronal survival, and synaptic plasticity. The unconjugated antibody is supplied as 100 µl per vial and is validated for Western blot detection in human, mouse, and rat samples. Researchers apply it across neuroscience and oncology workflows where aberrant NTRK2 activity is implicated, including characterization of BDNF/TrkB downstream signaling in brain tissue and in TrkB-expressing tumor models. For western blotting, lysates should be prepared with phosphatase inhibitors to preserve the phospho-epitope, and the phosphorylated receptor band is visualized at the expected molecular weight. The antibody is shipped refrigerated and is intended for research use only; store at 4°C and avoid repeated freeze-thaw cycles of the stock.