Anti-NTRK2 (phospho Y515) Antibody

This rabbit polyclonal antibody from Antibodies.com specifically recognizes NTRK2 (also known as TrkB) when phosphorylated at tyrosine 515, a key activation site within the intracellular domain that couples ligand binding to downstream signaling cascades. The reagent is supplied as 100 µl of unconjugated IgG, validated for immunofluorescence on human, mouse, and rat samples.

The phospho-Y515 epitope marks an early step in TrkB receptor activation following BDNF or NT-4 engagement, and detection of this modification is used to study neuronal differentiation, synaptic plasticity, and neurotrophin-driven signal transduction in fixed cells and tissue preparations. Because the reagent was raised against a phosphopeptide sequence centered on Y515, it reports the activated, signaling-competent pool of the receptor rather than total NTRK2 levels, enabling tracking of pathway engagement downstream of neurotrophin stimulation.