Anti-NTRK1 (phospho S791) Antibody

Raised in rabbit against a synthetic phosphopeptide spanning the activation-loop motif around residue 791 of human TRKA, this unconjugated polyclonal IgG from Antibodies.com selectively recognizes NTRK1 only when that site is phosphorylated, the modification that marks ligand-engaged receptor tyrosine kinase activity downstream of nerve growth factor (NGF) stimulation. Affinity purification over the phosphopeptide, with subtraction of non-phospho-reactive immunoglobulins by chromatography against the corresponding unphosphorylated peptide, yields a reagent suited to TRKA activation studies in neuronal and tumor cell models. The 200 µl liquid vial is supplied in PBS pH 7.4 with 150 mM NaCl, 0.02% sodium azide and 50% glycerol as a cryoprotectant; researchers should refrigerate the antibody short term and avoid repeated freeze-thaw cycles to preserve phospho-specific binding across the working shelf life. Cross-reactivity is verified on human, mouse and rat samples, supporting work on neurotrophin-driven TRKA signaling in sensory neuron development, nociceptive pathway biology, and the cancers driven by NTRK1 fusions such as LMNA-NTRK1 and TPM3-NTRK1, where receptor autophosphorylation status is increasingly used to stratify response to TRK inhibitor therapy. The unconjugated format is compatible with secondary antibody-based detection in Western blot and immunofluorescence workflows on methanol-fixed cells. Research use only.