Anti-NTE Antibody

Raised in rabbit and supplied as 100 µl of unconjugated serum, this polyclonal reagent from Antibodies.com targets neuropathy target esterase (NTE/PNPLA6), a patatin-domain phospholipase that maintains neuronal membrane lipid homeostasis and is the molecular initiator of organophosphate-induced delayed neuropathy. Validated for western blot and ELISA workflows, the antibody recognizes endogenous NTE in both human and mouse samples, supporting cross-species studies of motor neuron disease models and PNPLA6-linked inherited disorders including Boucher-Neuhäuser, Gordon Holmes, and Oliver-McFarlane syndromes. Typical applications include mapping PNPLA6 expression across brain and spinal cord lysates, characterizing differentiating neuronal cell lines, and probing subcellular distribution of the esterase in membrane fractionation experiments. For handling, aliquot on receipt and store at -20 °C, avoiding repeated freeze-thaw cycles and prolonged exposure to room temperature to preserve titer.