Anti-NT5C2 Antibody

This polyclonal antibody from Antibodies.com targets NT5C2 (cytosolic 5'-nucleotidase II), a metal-dependent hydrolase involved in nucleoside monophosphate dephosphorylation and purine salvage pathways. Raised in rabbit hosts and supplied at 100 µl as an unconjugated reagent, it supports Western blot and immunohistochemistry workflows on human samples. NT5C2 has attracted strong interest in hematological malignancy research because activating mutations drive resistance to thiopurine chemotherapy in relapsed B-cell and T-cell acute lymphoblastic leukemia, making this reagent useful for studies of relapse mechanisms, nucleotide pool regulation, and drug response pathways. Researchers investigating cytosolic phosphatase activity, 6-mercaptopurine metabolism, or leukemic clonal evolution can apply it to detect endogenous protein levels across cell line panels and primary tissue sections.