Anti-NT-proBNP (27-31) Antibody

This mouse monoclonal antibody from Antibodies.com targets the NT-proBNP (27-31) epitope, a defined peptide region within the N-terminal portion of pro-B-type natriuretic peptide. NT-proBNP is an inactive 76-amino-acid fragment released into circulation following cleavage of the proBNP precursor, primarily by ventricular cardiomyocytes in response to wall stress. The 27-31 epitope sits in the central segment of the peptide and is commonly used in immunoassays that distinguish NT-proBNP from the biologically active C-terminal BNP hormone.

The reagent is supplied as 1 mg of purified monoclonal antibody in liquid format, unconjugated, and raised in mouse. It is intended for research use in applications such as Western blot, immunohistochemistry, and ELISA-based detection of NT-proBNP in cardiac research and heart failure studies. Because NT-proBNP has a longer plasma half-life than BNP and is less affected by acute hemodynamic fluctuation, it is a routinely used biomarker for diagnosing and monitoring chronic and acute heart failure, and antibodies specific to defined epitopes such as 27-31 support selective capture or detection in paired-antibody assay configurations.