Anti-NRF2 Antibody

This polyclonal rabbit antibody targets NRF2 (NFE2L2), a master transcription factor that orchestrates the cellular antioxidant defense program. Under basal conditions, NRF2 is sequestered in the cytoplasm by KEAP1 and targeted for proteasomal degradation; oxidative or electrophilic stress disrupts this interaction, allowing NRF2 to translocate into the nucleus and bind antioxidant response elements (AREs) that drive expression of detoxifying and cytoprotective genes. Provided by Antibodies.com in an unconjugated format at 100 µl, the reagent detects endogenous NRF2 in human, mouse, and rat samples and is validated for Western blot, immunohistochemistry, and immunofluorescence workflows. Researchers studying oxidative stress signaling, carcinogenesis, neurodegeneration, and inflammatory pathways routinely use NRF2 antibodies to monitor pathway activation, KEAP1-NRF2 axis disruption, and downstream targets such as NQO1 and HMOX1. The polyclonal host response yields recognition of multiple epitopes on the target, an advantage when probing conformational or post-translationally modified forms of NRF2, and the unconjugated preparation allows flexible pairing with investigator-selected secondary reagents and fluorophore or enzyme choices.