Anti-NR3C1 Antibody

Raised in rabbit against the glucocorticoid receptor (Nuclear Receptor Subfamily 3 Group C Member 1), this polyclonal primary antibody from Antibodies.com detects NR3C1 in human, mouse, and rat samples. Validated for western blot, immunohistochemistry, and immunofluorescence, the unconjugated format gives researchers flexibility to pair the reagent with HRP, biotin, or fluorescent secondary antibodies suited to their detection platform.

NR3C1 is a ligand-activated transcription factor that mediates cellular responses to cortisol and synthetic glucocorticoids, making it a focal target in studies of stress-axis signaling, steroid hormone responsiveness, and inflammatory regulation. Polyclonal antibodies recognize multiple epitopes on the target, which can be advantageous when probing receptor isoforms, post-translational modifications such as phosphorylation, or species-specific sequence variants that a single monoclonal clone may miss.

Packaged as 100 µl of stock reagent, the vial supports multiple experimental runs at typical working dilutions. Aliquoting upon arrival and refrigerating for short-term use, with freezing for longer storage, helps preserve binding activity across repeated freeze-thaw cycles. Researchers frequently use this reagent to map receptor distribution and activation status in tissue sections, cell lysates, and cultured cells under basal or glucocorticoid-stimulated conditions.