Anti-NR2F6 Antibody

Nuclear Receptor subfamily 2 group F member 6 (NR2F6), also called EAR-2, is an orphan nuclear receptor that acts as a transcriptional repressor in immune signaling pathways, with particular relevance to T cell effector function and growing interest as an intracellular immune checkpoint regulator in tumor immunology. The Antibodies.com polyclonal reagent is raised in rabbit and supplied as an unconjugated antiserum at 100 µl per vial, suitable for Western blot, immunohistochemistry, and immunofluorescence workflows across human, mouse, and rat samples.

Researchers use this reagent to probe NR2F6 expression in lymphoid tissue, tumor-infiltrating lymphocytes, and cell line models, supporting studies of immune tolerance, autoimmune mechanisms, and immuno-oncology target validation. The polyclonal format provides multi-epitope recognition, which is useful when detecting low-abundance nuclear receptor protein in fixed or lysed specimens, and the unconjugated presentation allows flexible pairing with custom fluorophore- or enzyme-labeled secondary reagents for chromogenic or multiplex imaging. Storage at -20 °C in small aliquots is recommended to limit freeze-thaw cycles and preserve binding activity over multiple experiments.