Anti-NR0B2 Antibody

NR0B2, also known as Small Heterodimer Partner (SHP), is an atypical orphan nuclear receptor that acts as a transcriptional repressor in metabolic and signaling pathways, including bile acid synthesis, cholesterol homeostasis, and glucose regulation. The Anti-NR0B2 polyclonal reagent offered by Antibodies.com is raised in rabbit and supplied as an unconjugated preparation in a 50 µL vial, allowing laboratories to pair it with the secondary detection chemistry of their choice.

This polyclonal antibody has been validated for Western blot (WB) and immunohistochemistry (IHC) workflows and shows reactivity with Human, Rat, and Mouse samples, supporting cross-species experimental designs in hepatic biology, endocrinology, and nuclear receptor signaling research. The unconjugated format provides flexibility for chromogenic, fluorescent, or HRP-based detection, depending on the platform and tissue or lysate preparation.

Intended for research use only, this reagent suits studies exploring transcriptional repression mechanisms, nuclear receptor cross-talk, and the involvement of NR0B2 in metabolic and inflammatory contexts. End users are encouraged to titrate the antibody in their own sample preparations and to optimize antigen retrieval conditions for IHC on fixed tissue sections.