Anti-NR0B2 Antibody

This rabbit polyclonal antibody from Antibodies.com targets NR0B2 (Nuclear Receptor Subfamily 0 Group B Member 2), also referred to as the small heterodimer partner (SHP), an atypical orphan nuclear receptor that lacks a conventional DNA-binding domain and acts primarily as a transcriptional repressor in hepatic and enteroendocrine signaling pathways.

Supplied as 100 µl of unconjugated antisera, the reagent is validated for western blot, immunohistochemistry, and immunofluorescence workflows on human samples, and is raised in rabbit for detection with standard anti-rabbit secondary reagents. The polyclonal format provides recognition of multiple epitopes across the NR0B2 protein, which is advantageous when probing this regulator of bile acid synthesis, gluconeogenesis, and cholesterol homeostasis in liver, intestine, and pancreatic islet models.

Investigators working on metabolic disease, non-alcoholic fatty liver disease, or nuclear receptor signaling pathways can use this reagent to localize endogenous NR0B2 expression in fixed tissue sections and cultured cell preparations. For handling, store refrigerated at 4 °C for short-term use; aliquot upon arrival to limit freeze-thaw cycles and preserve antibody activity across repeated experiments.