Anti-NR0B2 Antibody

A polyclonal rabbit IgG reagent targeting NR0B2, the orphan nuclear receptor also referred to as SHP (Small Heterodimer Partner), supplied by Antibodies.com as a 50 µl liquid aliquot.

The unconjugated antibody recognizes endogenous human, mouse, and rat NR0B2 in western blot, immunohistochemistry, and immunofluorescence workflows. SHP operates as a transcriptional repressor central to hepatic bile acid, cholesterol, and glucose homeostasis, where it dampens farnesoid X receptor, liver X receptor, and constitutive androstane receptor signaling. Investigators apply this reagent to liver, gallbladder, and adrenal cortex tissue sections and lysates to map nuclear receptor crosstalk in metabolic disease, cholestasis, and steatohepatitis research models.

Aliquot on arrival and store refrigerated; protect from light and limit freeze-thaw cycles to preserve antigen-binding activity. Each vial contains a ready-to-dilute polyclonal preparation compatible with standard immunodetection buffers and HRP- or fluorophore-conjugated secondary reagents, supporting both membrane-based and tissue-imaging readouts. The 50 µl format provides enough material for multiple replicate blots, staining runs, and imaging panels.