Anti-NR0B2 Antibody

NR0B2 (nuclear receptor subfamily 0 group B member 2), also called the small heterodimer partner (SHP), is an atypical orphan nuclear receptor that lacks a conventional DNA-binding domain and instead acts as a transcriptional corepressor. This rabbit polyclonal IgG reagent from Antibodies.com is raised against the human protein and supplied as an unconjugated preparation at 100 µl, validated for western blot, immunohistochemistry, and immunofluorescence workflows on human, mouse, and rat samples.

The target plays a central feedback role in hepatic physiology: SHP is induced by activated farnesoid X receptor (FXR) and in turn represses CYP7A1 and CYP8B1, the rate-limiting enzymes of bile acid synthesis, while also modulating LRH-1, HNF4α, and PPARγ activity linked to glucose and lipid homeostasis. Researchers studying non-alcoholic fatty liver disease, cholesterol handling, or nuclear receptor crosstalk use this reagent to track SHP induction in liver sections and cell lysates.

As a polyclonal reagent, the antibody recognizes multiple epitopes on the 28 kDa SHP protein, which can strengthen signal in assays where a single monoclonal clone produces weak detection. For short-term use, working dilutions may be kept refrigerated at 4 °C, and aliquoting upon arrival helps preserve activity across repeated freeze-thaw cycles.