Anti-NQO1 Antibody

NQO1 (NAD(P)H:quinone oxidoreductase 1), also known as DT-diaphorase, is a cytosolic flavoenzyme that catalyzes the two-electron reduction of quinones to hydroquinones, protecting cells from oxidative damage and electrophilic stress. This rabbit polyclonal antibody from Antibodies.com targets the human NQO1 protein and is supplied as 100 µl of unconjugated antisera, validated for western blot and immunohistochemistry workflows. The reagent was raised in rabbit and recognizes a protein implicated in xenobiotic metabolism, redox homeostasis, and the cellular response to chemotherapeutics. NQO1 is overexpressed in many solid tumors, including lung, breast, and colorectal cancers, making it a frequent focus of studies on tumor biology, chemoprevention, and acquired drug resistance. Researchers use this reagent to probe NQO1 expression across cultured cell lines, tumor tissue microarrays, and lysates prepared from human samples, supporting investigations into quinone detoxification, oxidative stress pathways, and cellular defense mechanisms.