Anti-NPY1R Antibody

The Neuropeptide Y receptor Y1 (NPY1R) is a class A G-protein coupled receptor that binds neuropeptide Y along with related peptide YY and pancreatic polypeptide ligands, transducing signals linked to appetite regulation, anxiety, memory processing, and vascular tone. This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against NPY1R and validated for Western blot and immunohistochemistry workflows on human and mouse samples, supplied as 50 µl of ready-to-titrate stock.

The polyclonal format captures multiple epitopes across the receptor, which is useful when working with samples carrying polymorphism or when probing both full-length and truncated receptor variants. Validated applications include immunoblotting of cultured cell or tissue lysates to confirm receptor expression levels, and IHC on fixed sections for localization studies in regions such as the hypothalamus, hippocampus, and cortex, where NPY1R is abundantly expressed. Confirmed species reactivity covers human and mouse NPY1R, supporting translational work that bridges rodent disease models with patient-derived specimens.

Storage recommendations follow standard antibody handling: aliquot upon first use to limit repeated freeze-thaw cycles and store at -20°C or below for long-term stability, with short-term handling kept on ice. The 50 µl pack size accommodates several WB and IHC titration experiments, giving room to optimize working dilutions across multiple membranes or slide sets. Researchers investigating feeding behavior, stress responses, or NPY pathway involvement in oncology and cardiovascular disease will find this Antibodies.com reagent a consistent tool for NPY1R expression profiling.