Anti-NPRL2 Antibody

This unconjugated rabbit polyclonal antibody targets NPRL2 (NPR2 Like, GATOR1 Complex Subunit), a GTPase-activating component of the GATOR1 complex that restrains mTORC1 signaling when amino acids are scarce. Manufactured by Antibodies.com as a primary antibody reagent and supplied in a 100 µl vial, it has been validated for western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF) workflows against human, mouse, and rat samples.

NPRL2 sits at a tumor-suppressor locus on chromosome 3p21.31, frequently deleted in lung, renal, and breast carcinomas, making it a useful marker in cancer biology research. Investigators also apply this reagent to study GATOR1-dependent nutrient sensing, autophagy induction under amino acid starvation, and the rare familial focal epilepsy syndromes driven by GATOR1 subunit mutations. With no fluorophore or enzyme attached, the antibody is ready for custom conjugation to HRP, biotin, or any preferred reporter for individual assay designs.