Anti-NPC2 Antibody

This rabbit polyclonal antibody from Antibodies.com recognizes NPC2 (Niemann-Pick C2 protein), a small soluble lysosomal glycoprotein central to intracellular cholesterol trafficking. The unconjugated reagent is supplied as 100 µl of polyclonal antiserum and is validated for western blot (WB) and immunohistochemistry (IHC) on human and mouse specimens. NPC2 binds cholesterol and related sterols within late endosomal and lysosomal compartments, partnering with NPC1 to mediate lipid export, and loss-of-function mutations underlie Niemann-Pick disease type C2. Investigators working on lysosomal storage disorders, endosomal lipid metabolism, and cholesterol homeostasis use this reagent to probe endogenous NPC2 expression in cell and tissue lysates as well as fixed sections. The polyclonal format offers recognition of multiple epitopes on the target, which can help maintain signal across varied sample preparations.