Anti-NOX4 Antibody

Rabbit polyclonal antibody targeting NOX4 (NADPH oxidase 4), the constitutively active ROS-generating enzyme expressed in renal tubular epithelium, vascular smooth muscle, hepatocytes, and cardiac myocytes. Supplied as an unconjugated reagent in a 100 µL vial, this Antibodies.com primary antibody is validated for Western blot and immunohistochemistry applications across human, mouse, and rat samples.

NOX4 is a membrane-associated flavocytochrome of approximately 68 kDa that produces hydrogen peroxide rather than superoxide, distinguishing it from other NOX family members. Researchers apply this reagent to study oxidative stress signaling, fibrotic remodeling in kidney and liver models, vascular pathophysiology, and tumor microenvironments where NOX4-derived reactive oxygen species influence proliferation, migration, and inflammatory cascades.

For Western blot, full-length NOX4 resolves near 65–70 kDa depending on tissue and species. For IHC, citrate-buffer antigen retrieval is commonly applied to formalin-fixed paraffin sections. Aliquot the antibody upon arrival to limit freeze-thaw cycles; store frozen for long-term retention of polyclonal titer, and keep working aliquots refrigerated.