Anti-NOTCH4 Antibody

NOTCH4 (Neurogenic locus notch homolog protein 4) is a single-pass transmembrane receptor that plays central roles in vascular development, angiogenesis, and cell fate specification. This rabbit polyclonal antibody from Antibodies.com targets the human NOTCH4 protein and has been validated for Western blot detection of the endogenous receptor.

The reagent is supplied as 100 µl of liquid at 1 mg/ml in phosphate buffered saline (PBS) containing 15 mM sodium azide, at approximately pH 7.2. As an unconjugated polyclonal antibody, it offers researchers flexibility in selecting secondary reagents and labeling chemistries appropriate to their experimental design.

NOTCH4 signaling intersects with several physiological and pathological contexts, including endothelial cell behavior, tumor angiogenesis, and a range of solid tumor types in which aberrant Notch pathway activity contributes to disease progression. Investigators in vascular biology, oncology, and developmental signaling studies use this reagent to probe NOTCH4 expression in human cell lines and primary tissue lysates.

For handling, store refrigerated at 4°C for short-term use; for longer-term storage, aliquot the antibody and freeze at -20°C to preserve activity. Minimize freeze-thaw cycles. The sodium azide in the formulation prevents microbial contamination, supporting standard aseptic benchtop handling.