Anti-NOTCH3 Antibody

This unconjugated polyclonal antibody from Antibodies.com is raised in rabbit against NOTCH3, a transmembrane receptor that regulates vascular smooth muscle maturation, T-cell lineage decisions, and angiogenic signaling. Validation data support western blot and immunohistochemistry workflows on human, mouse, and rat samples, with immunofluorescence also listed as an applicable method. Each vial contains 100 µl of reagent suitable for probing endogenous NOTCH3 in cell lysates, frozen tissue sections, and cultured cell monolayers, including research on CADASIL small-vessel disease and on tumors such as lung squamous cell carcinoma in which NOTCH3 is recurrently mutated. The unconjugated format allows pairing with HRP, biotin, or fluorophore-labelled secondary antibodies according to the detection chemistry required, and storage at -20 degrees C with single use aliquoting preserves reagent performance across freeze-thaw cycles. Researchers using this reagent commonly work in vascular biology, neuropathology, and cancer signaling laboratories.