Anti-NOP56 Antibody

NOP56 (NOP56 Ribonucleoprotein Homolog) is a conserved nucleolar protein that forms the structural core of the box C/D small nucleolar ribonucleoprotein (snoRNP) complex, where it directs 2'-O-methylation of ribosomal RNA during ribosome biogenesis. Polyclonal antibodies against this target let researchers investigate nucleolar architecture, snoRNP assembly, and rRNA processing pathways across mammalian systems.

Supplied by Antibodies.com as 100 µL of unconjugated rabbit polyclonal IgG, this reagent is validated for Western blot detection of endogenous NOP56 in human, mouse, and rat samples. The host species is rabbit, the clonality is polyclonal, and the isotype is IgG, with no fluorophore or enzyme conjugate attached, allowing users to pair it with secondary detection reagents of their choice. It supports studies of nucleolar stress responses, ribosome biogenesis, and disease models in which NOP56 function has been implicated, including infantile-onset striatonigral degeneration associated with NOP56 mutations and altered NOP56 expression reported in several cancer types. Standard Western blot protocols using chemiluminescent or colorimetric secondary antibodies are typically compatible with this product, and aliquoting upon arrival helps preserve activity across multiple experiments.