Anti-NOL3 Antibody

NOL3, also known as ARC (Apoptosis Repressor with Caspase Recruitment Domain), is a member of the inhibitor of apoptosis protein family. This unconjugated polyclonal reagent from Antibodies.com is raised in rabbit and validated for western blot and immunofluorescence workflows across human, mouse, and rat samples. The antibody is supplied as a 100 µl liquid aliquot and should be stored refrigerated at 4°C for short-term use, with aliquoting recommended to limit freeze-thaw cycles and preserve binding performance over long-term storage. ARC/NOL3 acts as an endogenous caspase inhibitor that suppresses programmed cell death, so researchers studying cardiac myocyte survival, neuronal responses to ischemic injury, and tumor cell resistance commonly use it to track endogenous ARC protein levels and subcellular localization. Each laboratory should titrate the reagent against its own tissue preparation, working under standard immunofluorescence and western blot protocols for fixed cells and whole lysates respectively. As a polyclonal reagent, it provides multiple epitope recognition of ARC, which can be useful when working across the human, mouse, and rat model systems listed in its reactivity profile.