Anti-NOG Antibody

This rabbit polyclonal antibody from Antibodies.com targets Noggin (NOG), a secreted extracellular antagonist that binds and inhibits bone morphogenetic proteins (BMP-2, BMP-4, and BMP-7). By sequestering BMP ligands, Noggin plays a pivotal role in neural plate induction, chondrogenesis, joint formation, and skeletal patterning, making this reagent useful for developmental biology and stem cell differentiation studies.

Validated for Western blot applications, the antibody is supplied as 50 µl of unconjugated IgG in a vial format, ready for routine immunoblotting of endogenous Noggin in mouse and rat tissue lysates. The polyclonal format offers recognition of multiple epitopes on the Noggin protein, supporting consistent detection across experimental conditions involving BMP-regulated tissues such as cartilage primordia, neural tube, and developing bone.

For optimal stability, aliquot the antibody upon arrival and store at -20°C, avoiding repeated freeze-thaw cycles to preserve binding activity. Researchers investigating BMP signaling pathways, neural crest development, or hereditary skeletal disorders such as proximal symphalangism will find this Antibodies.com reagent a reliable tool for characterizing Noggin expression patterns in murine and rat model systems.