Anti-NME3 Antibody

This rabbit polyclonal IgG reagent from Antibodies.com targets NME3 (NME/NM23 nucleoside diphosphate kinase 3), a 19 kDa enzyme that anchors to the mitochondrial outer membrane and drives mitochondrial fusion. The unconjugated, affinity-purified antibody is supplied in a 200 µl vial and is validated for western blot (WB), immunohistochemistry (IHC), and immunocytochemistry/immunofluorescence (ICC/IF) workflows, with documented reactivity against human, mouse, and rat samples.

Encoded by the NME3 gene (Gene ID 4832), the target plays a major role in nucleoside triphosphate synthesis, transferring the gamma phosphate of ATP to nucleoside diphosphates via a phosphorylated active-site intermediate. Beyond nucleotide metabolism, NME3 participates in DNA-repair mechanisms through interactions with NEK8, CEP164, and ANKS6, and has been linked to granulocyte differentiation and apoptosis in normal hematopoiesis. Known aliases include DR-nm23, NDPKC, NM23-H3, and NDPK-C, with UniProt accession Q13232. The polyclonal format allows recognition of multiple epitopes on the target, supporting detection across varied expression levels in cell lysates and tissue sections.

Unconjugated presentation gives researchers flexibility to pair the reagent with their preferred secondary conjugate and detection system. For continuous use, store at -20 °C and avoid repeated freeze-thaw cycles to preserve antibody activity across multiple experiments.