Anti-NLRP3 Antibody

This rabbit polyclonal antibody from Antibodies.com targets the NLRP3 protein (NACHT, LRR and PYD domains-containing protein 3), a key inflammasome component implicated in innate immunity and inflammatory signaling. Raised in rabbit and purified as an IgG isotype, the unconjugated reagent is supplied as a 50 µl aliquot and is validated for Western blot and immunofluorescence applications across human, mouse, and rat samples. Researchers studying pyroptosis, IL-1β maturation, caspase-1 activation, and sterile inflammation pathways commonly use NLRP3-targeting antibodies to monitor inflammasome assembly in macrophages, microglia, and epithelial models. For best results, store the vial at 4 °C for short-term use or aliquot and freeze at −20 °C for longer-term storage, avoiding repeated freeze-thaw cycles to preserve binding activity.