Anti-NLRC4 Antibody

NLRC4 is a cytoplasmic pattern recognition receptor that assembles canonical inflammasomes upon detection of bacterial flagellin and components of type III secretion systems, and it is widely studied in the context of innate immunity, caspase-1 driven pyroptosis, and the maturation of IL-1β and IL-18. This rabbit polyclonal reagent from Antibodies.com is raised against the human NLRC4 protein and is validated for Western blot (WB) and immunohistochemistry (IHC) workflows, including immunoblotting of cultured cell lysates and staining of fixed tissue sections for basic immunology and infectious disease research use only.

The antibody is supplied as a 100 µL vial of unconjugated polyclonal IgG at 1 mg/mL in PBS containing 0.1% sodium azide and 50% glycerol as a cryoprotectant, allowing convenient storage at -20 °C in working aliquots to limit repeated freeze-thaw cycles. Investigators characterising gain-of-function NLRC4 variants associated with autoinflammatory syndromes, or profiling inflammasome assembly in macrophage and epithelial infection models, can pair this primary antibody with appropriate secondary reagents and isotype controls.