Anti-NLE1 Antibody

This rabbit polyclonal IgG antibody recognizes NLE1 (Notchless E3 Ubiquitin Protein Ligase 1), a WD40 repeat-containing protein best characterized for its contribution to the PeBoW complex, where it participates in 60S ribosomal subunit maturation and ribosome biogenesis, and for its modulatory role in the Notch signaling pathway. Produced by Antibodies.com as an unconjugated primary reagent in a 200 µL volume, the antibody is validated for Western blot detection of the human NLE1 target and is supplied as a liquid aliquot suitable for standard immunoblotting workflows. The polyclonal format allows recognition of multiple epitopes across the protein, which can be useful when probing endogenous expression in cell lysates or tissue extracts where single-epitope monoclonal reagents may fall short. The reagent should be refrigerated and handled in aliquots to preserve antibody activity through repeated freeze-thaw cycles. Researchers studying ribosome biogenesis, Notch pathway regulation, or conditions linked to NLE1 dysfunction such as Dubowitz syndrome will find this reagent a practical addition to a Western blot-based expression profiling workflow.