Anti-NFKBIB Antibody

The Anti-NFKBIB polyclonal antibody from Antibodies.com targets IκBβ (NF-kappa-B inhibitor beta), a cytoplasmic anchoring protein that retains NF-κB transcription factor complexes in an inactive state under resting conditions. Raised in rabbit and supplied as 100 µl of unconjugated antiserum, this reagent is validated for Western blot, immunohistochemistry, and immunofluorescence workflows on human samples.

NFKBIB contributes to the canonical NF-κB signaling axis and is studied in the context of immune cell activation, inflammatory cytokine responses, and transcriptional regulation downstream of TNF receptor and Toll-like receptor engagement. Researchers investigating IκB family dynamics, stimulus-induced IκBβ degradation, or the relocalization of p65/p50 complexes can use this reagent to track endogenous protein levels in both fixed tissue and lysed cellular material.

The polyclonal format increases the likelihood of recognizing multiple epitopes on IκBβ, which is useful when probing denatured targets on membranes or formalin-fixed paraffin-embedded sections. For best results, refrigerate working aliquots for short-term use and freeze at -20 °C for longer-term storage, avoiding repeated freeze-thaw cycles to preserve binding activity across experiments.