Anti-NFkB-p65 (Ab-435) Antibody

This unconjugated Rabbit polyclonal antibody from Antibodies.com is raised against an epitope surrounding residue 435 of the NFkB-p65 (RelA) transcription factor subunit, a central component of the canonical NF-κB signaling pathway that regulates inflammatory responses, apoptosis, and oncogenic transcription programs.

Validated applications include Western blot analysis of cell culture lysates and immunohistochemistry on fixed tissue sections, making the reagent useful for both biochemical and histology-based pathway studies. Reported cross-reactivity spans Human, Mouse, Rat, and Monkey samples, so the antibody supports translational work across multiple mammalian model systems and human clinical specimens.

The polyclonal format recognizes multiple epitopes on the p65 subunit, which is helpful when probing post-translational modifications or working with partially denatured antigen. The product is supplied as a 100 µl liquid aliquot in a vial. For short-term use, keep refrigerated; for long-term storage, aliquot and freeze at -20°C, avoiding repeated freeze-thaw cycles to preserve binding activity.