Anti-NFASC Antibody

Rabbit polyclonal antibody from Antibodies.com directed against NFASC (Neurofascin), a neuronal cell adhesion molecule essential for the assembly and stabilization of nodes of Ranvier along myelinated axons. This unconjugated reagent is supplied as 100 µl at 1 mg/ml in PBS containing 0.1% sodium azide and 50% glycerol, a buffer combination that preserves antibody activity at standard refrigeration temperatures. Validated for western blot and immunohistochemistry, the antibody cross-reacts with NFASC in human, mouse, and rat tissue samples, making it useful across comparative neuroscience studies and developmental myelination research. The polyclonal format provides recognition of multiple epitopes, supporting detection of full-length Neurofascin isoforms such as NFASC-186 and NFASC-155 that are differentially expressed at paranodal and nodal axonal regions. Researchers investigating autoimmune neuropathies, axonal domain organization, or Schwann cell–axon interactions routinely apply this reagent to characterize nodal architecture in peripheral nerve sections.