Anti-NF2 (phospho S518) Antibody - Identical to Abcam (ab131473)

This rabbit polyclonal IgG antibody from Antibodies.com specifically recognizes Neurofibromin 2 (Merlin) only when phosphorylated at serine 518, a post-translational modification that drives the protein into its closed, growth-suppressive conformation. Supplied as 50 µl of unconjugated antiserum, the reagent is validated for Western blot and immunofluorescence workflows and is used to probe merlin regulation, NF2-related tumor suppressor signaling, and the wider ERM-family cytoskeletal network.

Each lot is raised against a phospho-S518 peptide, allowing researchers to distinguish the active, closed pool of Merlin from the open, growth-permissive pool in human, mouse, and rat samples. Routine applications include Western blot analysis of merlin phosphorylation in response to cell-cell contact, serum withdrawal, or pathway perturbation, alongside immunofluorescence labeling of merlin at the cortical cytoskeleton and membrane ruffles.