Anti-NF-M (K591) Antibody

Raised in rabbit, this unconjugated polyclonal reagent targets the K591 epitope on Neurofilament Medium (NF-M), a roughly 145 kDa intermediate filament protein that forms part of the axonal cytoskeleton in mature neurons. Validated for immunohistochemistry on human tissue, the antibody is supplied at 1 mg/ml in phosphate buffered saline with 0.05% sodium azide at approximately pH 7.2, in a 50 µl vial suitable for direct use or further dilution. Antibodies.com distributes this reagent to investigators studying neuronal architecture, neurofilament accumulation in neurodegenerative disease, and cytoskeletal organization in peripheral nerve. Because NF-M becomes heavily phosphorylated along its tail domain in vivo, antibodies mapping to defined residues in this region are commonly used to distinguish axonal from somatic neurofilament pools and to monitor injury-related phosphorylation changes in experimental models.